An opponent process for alcohol addiction based on changes in endocrine gland mass

Source:

Karin, O., Raz, M., & Alon, U. (2021). An opponent process for alcohol addiction based on changes in endocrine gland mass. Iscience, 102127.

Highlights

•Addiction involves tolerance and withdrawal over weeks

•Model of the HPA-axis and β-endorphins explains tolerance and withdrawal

•Effects due to changes in the functional mass of endocrine glands

•Fold-change detection makes circuit prone to addiction but boosts learning